Beaufils B
Hôpital Corentin Celton, Issy-les-Moulineaux.
Encephale. 1996 Jun;22 Spec No 2:41-3.
Therapy with classical neuroleptics is not effective enough and its adverse effects are quite disabling, especially in chronic or negative schizophrenia; that is probably why adjunctive therapy is so common. Still conclusive evidence concerning the potential benefit of one or another therapeutic association is scarce. Intrinsic heterogeneity of schizophrenias and tremendous methodological problems constitute plausible explanations. Besides studies are usually realised among unselected patients. Available data about adjunctive therapy with anticholinergics, propranolol, antidepressants, benzodiazepines, lithium and carbamazepine are briefly reviewed here.
使用传统抗精神病药物进行治疗的效果不够显著，且其副作用相当严重，尤其是在慢性或阴性精神分裂症患者中；这可能就是辅助治疗如此普遍的原因。然而，关于某一种或另一种治疗组合潜在益处的确凿证据却很匮乏。精神分裂症的内在异质性以及巨大的方法学问题是合理的解释。此外，研究通常是在未经筛选的患者中进行的。本文简要综述了有关抗胆碱能药物、普萘洛尔、抗抑郁药、苯二氮䓬类药物、锂盐和卡马西平辅助治疗的现有数据。
