Bosman C, Bisceglia M, Quirke P
Department of Experimental Medicine and Pathology, La Sapienza University, Rome.
Pathologica. 1996 Feb;88(1):8-17.
An electron microscopic (EM) study of 25 Kaposi's sarcomas (KS) (24 cutaneous lesions, 1 lymphnodal) from 23 patients, mainly sporadic in type, has enabled us to study both the spindle and endothelial cells seen by light microscopy (LM) with the conclusion that they have both a fibroblastic-like EM aspect. Both cell types manifested a spindle shape with oval and occasionally notched nuclei and a reticular pattern of nucleoli. The cytoplasm was characterized by numerous rough endoplasmic reticulum cisternae with few other organelles. The plasma membranes consistently lacked an external or basal membrane and failed to show true cell junctions. In cells delimiting erythrocytes containing spaces it was never possible to document Weibel-Palade (W.-P.) bodies or plasmalemmal vesicles. Unusual findings such as ferritin loaded phagosomes, microtubular reticular structures (MTRS), intracisternal crystalline inclusions (ICCI), multivesicular bodies (MVB), acanthosomic vesicles (AV) and test-tube inclusions or ring-shaped forms (TTI/RSF) were occasionally seen in both sporadic and epidemic KS. The authors discuss the non specific nature of these latter findings.
对23例患者的25例卡波西肉瘤（KS）（24例皮肤病变，1例淋巴结病变）进行电子显微镜（EM）研究，这些病例主要为散发性，这使我们能够对光镜（LM）下所见的梭形细胞和内皮细胞进行研究，得出的结论是它们在电子显微镜下均具有成纤维细胞样外观。两种细胞类型均呈梭形，核呈椭圆形，偶尔有切迹，核仁呈网状。细胞质的特征是有许多粗面内质网池，其他细胞器较少。质膜始终缺乏外膜或基膜，也未显示真正的细胞连接。在界定含红细胞间隙的细胞中，从未发现魏贝尔-帕拉德（W.-P.）小体或质膜小泡。在散发性和流行性KS中偶尔可见一些不寻常的发现，如含铁蛋白的吞噬体、微管网状结构（MTRS）、池内结晶包涵体（ICCI）、多囊泡体（MVB）、棘状小泡（AV）以及试管状包涵体或环形结构（TTI/RSF）。作者讨论了这些后发现象的非特异性。
