Walter P, Philippe E, Khalil T, Nguemby-Mbina C, Chamlian A
Ann Pathol. 1984 Jan-Mar;4(1):19-25.
Kaposi's sarcoma is a multiform mesenchymal neoplasm of uncertain histogenesis but of possible viral origin. Several anatomo-clinical forms have been described the cutaneous nodular lesion being the most common and at highest frequency in equatorial Africa. Eighteen of such typical lesions were reported; their morphology was uniform and associated: 1) spindle cells, 2) an excess of vascular spaces composed of intratumoral intercellular slits and of intra and peritumoral well structured vessels, 3) a lymphoplasmocytic inflammatory infiltration. The lesions of the other and less common forms of Kaposi's sarcoma associated the same histological features in variable combination. At one end of the histological spectrum the lesions are essentially composed of irregular capillaries with few spindle cells, at the other end the tumor is a highly cellular neoplasm with few or no angiogenic features. The vascular structure of the typical lesions appeared clearly at the ultrastructural level. Most tumor cells were of endothelial type and formed cylinders with virtual or large central lumina, reminiscing of vascular sprouts. Pericyte-like cells were also present. In one the three ultrastructurally investigated cases, a tumor cell of the endothelial type contained intranuclear herpes virus like inclusions, group to which belongs the cytomegalovirus (CMV), a possible promoter of Kaposi's sarcoma.
卡波西肉瘤是一种组织发生不明但可能源于病毒的多形性间质性肿瘤。已描述了几种解剖学临床类型，皮肤结节性病变是赤道非洲最常见且发生率最高的类型。报告了18例此类典型病变；它们的形态一致且具有以下特征：1）梭形细胞，2）由肿瘤内细胞间裂隙以及肿瘤内和肿瘤周围结构良好的血管组成的过多血管间隙，3）淋巴细胞性炎症浸润。卡波西肉瘤其他较不常见类型的病变以不同组合呈现相同的组织学特征。在组织学谱系的一端，病变主要由不规则毛细血管组成，梭形细胞很少；在另一端，肿瘤是一种细胞高度丰富的肿瘤，血管生成特征很少或没有。典型病变的血管结构在超微结构水平清晰可见。大多数肿瘤细胞为内皮型，形成具有实质或大中央管腔的圆柱体，让人联想到血管芽。也存在类周细胞。在三个经超微结构研究的病例中，有一个内皮型肿瘤细胞含有核内疱疹病毒样包涵体，巨细胞病毒（CMV）属于该病毒群，它可能是卡波西肉瘤的促进因子。
