Holzhausen H J, Stiller D, Sachs M
Institut für Pathologische Anatome, Martin-Luther-Universität Halle - Wittenberg, DDR.
Zentralbl Allg Pathol. 1988;134(4-5):435-47.
Histological and electron-microscopic studies were conducted into biopsy material from cases of what is called the classical type of idiopathic Kaposi's sarcoma without acquired immunodeficiency syndrome. Ultrastructural analysis was conducted, with the view to characterizing a possible progenitor cell from which the angioblastic and fibroblastic elements were likely to originate. The biopsy material had been obtained from two males, aged 86 or 83 years, who had been afflicted with the disease for 18 or 8 years. The nodular lesions were typical of Kaposi's sarcoma and were, histologically, made up of variable mixtures of vascular and spindle cell elements. The angiomatous structures were a capillary meshwork or sinusoidal patterns lined by atypical endothelial cells. The spindle cell areas contained large numbers of slit-like spaces which were without endothelial lining but were stuffed with erythrocytes. Flattened endothelioid cells were recordable from semi-thin-sections of some clefts. Haemosiderin was, typically, deposited in places. Electron microscopically, the endothelial cells of vascular channels exhibited varying amounts of characteristic organelles, such as Weibel-Palade bodies, microfilaments and pinocytotic vesicles as well as basal membranes. Cells with typical endothelial markers, too, were detectable in solid sprouts or in capillary-like differentiations with narrow or small lumina. The spindle cell tumour areas consisted of fibroblastic cells with plenty of rough endoplasmic reticulum and surrounded by material of basal membrane nature. Also visible were solid, sprout-type multilayer cell complexes surrounded by basal membranes which exhibited undifferentiated or primitive cellular forms, endothelioid and pericytic. Transitional forms from these complexes to the above vascular tumours or the spindle-cell formations were detectable. These ultrastructural findings might be interpreted to the effect that an angioblastically determined mesenchymal cell, a so-called endothelioblast, was thinkable and was discussed as the precursor cell of atypical vascular and spindle cell proliferation in Kaposi's sarcoma.
对所谓无获得性免疫缺陷综合征的经典型特发性卡波西肉瘤病例的活检材料进行了组织学和电子显微镜研究。进行了超微结构分析，目的是鉴定血管母细胞和成纤维细胞成分可能起源的潜在祖细胞。活检材料取自两名男性，年龄分别为86岁和83岁，患病时间分别为18年和8年。结节性病变是卡波西肉瘤的典型表现，组织学上由血管和梭形细胞成分的不同混合物组成。血管瘤样结构为毛细血管网或由非典型内皮细胞衬里的窦状模式。梭形细胞区域含有大量无内皮衬里但充满红细胞的裂隙样间隙。在一些裂隙的半薄切片中可记录到扁平的内皮样细胞。含铁血黄素通常沉积在某些部位。电子显微镜下，血管通道的内皮细胞表现出不同数量的特征性细胞器，如Weibel-Palade小体、微丝和吞饮小泡以及基底膜。在实体芽或管腔狭窄或较小的毛细血管样分化中也可检测到具有典型内皮标记的细胞。梭形细胞瘤区域由含有大量粗面内质网并被基底膜样物质包围的成纤维细胞组成。还可见到被基底膜包围的实体芽型多层细胞复合体，这些复合体表现出未分化或原始的细胞形式，即内皮样和周细胞样。从这些复合体到上述血管肿瘤或梭形细胞形成的过渡形式也可检测到。这些超微结构发现可能意味着，可以设想一种血管母细胞性确定的间充质细胞，即所谓的内皮母细胞，并将其作为卡波西肉瘤中非典型血管和梭形细胞增殖的前体细胞进行讨论。
