Micellar electrokinetic chromatography perspectives in drug analysis.

Micellar electrokinetic chromatography (MEKC) has become a popular mode among several capillary electromigration techniques. Most drug analyses can be performed by using MEKC because of its wide applicability. Enantiomer separation, separation of closely related peptides and isotopic compounds, separation of very complex mixtures, determination of drugs in the biological samples, etc., can be successfully achieved by MEKC. This review surveys typical applications of MEKC analysis. Recent advances in MEKC, especially with pseudo-stationary phases, are described. Modes of electrokinetic chromatography including MEKC, a separation theory of MEKC and selectivity manipulation in MEKC are also briefly mentioned.