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喹唑啉酮衍生物：胆囊收缩素受体的合成与结合评估

Quinazolinone derivatives: synthesis and binding evaluation on cholecystokinin receptors.

作者信息

Varnavas A, Lassiani L, Luxich E, Zacchigna M, Boccù E

机构信息

Dipartimento di Scienze Farmaceutiche, Università di Trieste, Italy.

出版信息

Farmaco. 1996 May;51(5):333-9.

PMID:8767843
Abstract

A series of 2-methyl-3-amino-4(H)-quinazolinone and of 2-phenyl-3-amino-4(H)-quinazolinone derivatives were synthesized and examined for their CCK receptor affinities. These compounds displayed micromolar affinities for CCK-B rather than CCK-A receptor and the obtained results confirm that the 4(3H)-quinazolinone nucleous represent a useful template for the development of selective CCK-B receptor ligands.

摘要

合成了一系列2-甲基-3-氨基-4(H)-喹唑啉酮和2-苯基-3-氨基-4(H)-喹唑啉酮衍生物，并检测了它们对CCK受体的亲和力。这些化合物对CCK-B受体而非CCK-A受体表现出微摩尔级的亲和力，所得结果证实4(3H)-喹唑啉酮核是开发选择性CCK-B受体配体的有用模板。

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