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面对微生物耐药性,生物制剂和新型给药系统的重要性日益凸显。

Evolving importance of biologics and novel delivery systems in the face of microbial resistance.

作者信息

Bowersock Terry L

机构信息

Pharmacia Animal Health, 7923-190-353, 7000 Portage Road, Kalamazoo, MI 49001-0199, USA.

出版信息

AAPS PharmSci. 2002;4(4):E33. doi: 10.1208/ps040433.

DOI:10.1208/ps040433
PMID:12646005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2751322/
Abstract

Methods to control infectious diseases in livestock are growing in importance. As the size of the average farm increases - for poultry, dairy and beef cattle, swine, and fish - the risk of rapid spread of infectious diseases increases as well. This increases the need for alternative methods of control of infectious agents. Improvements in specific immunogens, adjuvants, and delivery systems are needed to meet the demand for vaccines to ensure a healthy and safe meat supply. This article explores the challenges, trends, and recent advances in the control of infectious diseases through the use of biologics.

摘要

控制家畜传染病的方法正变得越来越重要。随着平均农场规模的扩大——家禽、奶牛、肉牛、猪和鱼类养殖均是如此——传染病迅速传播的风险也在增加。这就增加了对控制传染源的替代方法的需求。需要改进特定免疫原、佐剂和递送系统,以满足对疫苗的需求,确保肉类供应健康安全。本文探讨了通过使用生物制品控制传染病方面的挑战、趋势和最新进展。

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本文引用的文献

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Bacterial toxins as tools for mucosal vaccination.细菌毒素作为黏膜疫苗接种的工具。
Drug Discov Today. 2002 Feb 15;7(4):247-58. doi: 10.1016/s1359-6446(01)02139-0.
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Comparison of culture, PCR and immunoassays for detecting Escherichia coli O157 following enrichment culture and immunomagnetic separation performed on naturally contaminated raw meat products.对天然污染的生肉产品进行富集培养和免疫磁珠分离后,比较培养法、聚合酶链反应(PCR)和免疫测定法检测大肠杆菌O157的效果。
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Present and future of veterinary viral vaccinology: a review.兽医病毒疫苗学的现状与未来:综述
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5
Towards development of an edible vaccine against bovine pneumonic pasteurellosis using transgenic white clover expressing a Mannheimia haemolytica A1 leukotoxin 50 fusion protein.利用表达溶血曼氏杆菌A1白细胞毒素50融合蛋白的转基因白三叶草开发抗牛肺炎巴氏杆菌病可食用疫苗。
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Aquaculture pharmaceuticals and biologicals: current perspectives and future possibilities.水产养殖用药品和生物制品:当前观点与未来可能性
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Vet Clin North Am Small Anim Pract. 2001 May;31(3):473-92, v-vi. doi: 10.1016/s0195-5616(01)50603-8.
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