爵床中木脂素及其糖苷的抗病毒活性

Antiviral activity of lignans and their glycosides from Justicia procumbens.

作者信息

Asano J, Chiba K, Tada M, Yoshii T

机构信息

Laboratory of Bio-organic Chemistry, Tokyo University of Agriculture and Technology, Japan.

出版信息

Phytochemistry. 1996 Jun;42(3):713-7. doi: 10.1016/0031-9422(96)00024-6.

DOI:10.1016/0031-9422(96)00024-6

PMID:8768323

Abstract

Ten antiviral lignans, seven known (justicidins A, B, C and D, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate) and three new compounds, justicidinosides A (justicidin C 6'-O-glucoside), B (justicidin A 6'-O-glucoside) and C (justicidin B 6'-O-glucoside), were isolated from a methanolic extract of the aerial parts of Justicia procumbens var. leucantha. Justicidins A and B, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate showed strong antiviral activity (the MIC were less than 0.25 microgram ml-1, respectively) against vesicular stomatitis virus and low cytotoxicity (the MTC were larger than 31 micrograms ml-1, respectively) against cultured rabbit lung cells (RL-33).

摘要

从白花爵床地上部分的甲醇提取物中分离出10种抗病毒木脂素，其中7种为已知化合物（爵床脂素A、B、C和D、二叶豆素、二叶豆素芹菜糖苷和二叶豆素芹菜糖苷-5-乙酸酯），3种为新化合物，即爵床脂苷A（爵床脂素C 6'-O-葡萄糖苷）、B（爵床脂素A 6'-O-葡萄糖苷）和C（爵床脂素B 6'-O-葡萄糖苷）。爵床脂素A和B、二叶豆素、二叶豆素芹菜糖苷和二叶豆素芹菜糖苷-5-乙酸酯对水疱性口炎病毒显示出较强的抗病毒活性（MIC分别小于0.25微克/毫升），对培养的兔肺细胞（RL-33）的细胞毒性较低（MTC分别大于31微克/毫升）。