Lara Suriñach N, Franch Nadal J, Morató Griera J, Egido Polo A, Puig Galy J, Castillejo Medina J
ABS Raval Sud, Barcelona.
Aten Primaria. 1996 Jun 15;18(1):3-8.
To study the association of dyslipemia with macroangiopathy in patients with type II diabetes mellitus.
Descriptive crossover study.
An urban health district with a socially and economically depressed elderly population.
A randomised sample among the diabetics registered in the health district (n = 449).
Different factors in the lipidic profile were studied, as was the presence of diabetic macroangiopathy and some of the associated risk factors. The following were considered cut-off figures with a predictive value of cardiovascular risk: overall cholesterol >or= 240 mg/dl (40% of the sample), HDL < 35 mg/dl (27%), LDL >or= 160 mg/dl (43%), triglycerides >or= 200 mg/dl (25%), atherogenic index >or= 4.5 (73%) and HDL/LDL balance >or= 0.2 (83%). 85.5% of the diabetics in the sample presented one of the lipidic disorders mentioned above. In the multivariant analysis only hypertriglyceridaemia was associated with a higher prevalence of peripheral vasculopathy.
A high percentage of patients with type II DM presented disorders in their lipidic profile. But, unlike the norm in the general population, only hypertriglyceridaemia displayed a statistically significant association with diabetic macroangiopathy. The role of the other dyslipemic factors was limited.
研究2型糖尿病患者血脂异常与大血管病变之间的关联。
描述性交叉研究。
一个社会经济状况较差的老年人口聚居的城市健康区。
从该健康区登记的糖尿病患者中随机抽取的样本（n = 449）。
研究了血脂谱中的不同因素，以及糖尿病大血管病变的存在情况和一些相关危险因素。以下指标被视为具有心血管疾病风险预测价值的临界值：总胆固醇≥240 mg/dl（占样本的40%），高密度脂蛋白< 35 mg/dl（27%），低密度脂蛋白≥160 mg/dl（43%），甘油三酯≥200 mg/dl（25%），致动脉粥样硬化指数≥4.5（73%），高密度脂蛋白/低密度脂蛋白比值≥0.2（83%）。样本中85.5%的糖尿病患者存在上述血脂异常之一。在多变量分析中，只有高甘油三酯血症与外周血管病变的较高患病率相关。
高比例的2型糖尿病患者存在血脂异常。但是，与一般人群的情况不同，只有高甘油三酯血症与糖尿病大血管病变存在统计学上的显著关联。其他血脂异常因素的作用有限。
