Tkác I, Moscovic F, Molcányová A, Lazúr J, Takác M
IVth Clinic of Medicine, School of Medicine, Safárik University, Kosice, Czechoslovakia.
Cor Vasa. 1990;32(4):311-9.
The levels of some cardiovascular risk factors (lipids, apolipoproteins and fibrinogen) were measured in groups of Type-2 diabetic patients with lower limb proximal (ileofemoral) and distal (trifurcational) artery macroangiopathy, diagnosed by Doppler ultrasound, and in a group of diabetics without macroangiopathy. The highest mean levels of total and LDL-cholesterol, apolipoprotein B and triacylglycerols were observed in patients with proximal vessel involvement. Significant correlations were found between the thigh/arm index and total cholesterol, LDL-cholesterol, apolipoprotein B and stroke prevalence. On the other hand, a significant correlation was found between ankle/thigh index and fibrinogen. The results of the study suggest that different pathogenetic mechanisms may play a role in the development of ileofemoral and trifurcational vessel disease.
通过多普勒超声诊断，对患有下肢近端（髂股）和远端（三叉分支）动脉大血管病变的2型糖尿病患者组以及无大血管病变的糖尿病患者组，测量了一些心血管危险因素（脂质、载脂蛋白和纤维蛋白原）的水平。在近端血管受累的患者中，观察到总胆固醇和低密度脂蛋白胆固醇、载脂蛋白B和三酰甘油的平均水平最高。发现大腿/手臂指数与总胆固醇、低密度脂蛋白胆固醇、载脂蛋白B和中风患病率之间存在显著相关性。另一方面，发现踝/大腿指数与纤维蛋白原之间存在显著相关性。研究结果表明，不同的发病机制可能在髂股血管和三叉分支血管疾病的发展中起作用。
