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[缺血期小脑皮质分子水平突触池的局灶性重组模式]

[The patterns of focal reorganization of the synaptic pool at the molecular level of the cerebellar cortex in the ischemic period].

作者信息

Semchenko V V, Sergeeva E D, Stepanov S S

出版信息

Morfologiia. 1996;109(1):7-11.

PMID:8768556
Abstract

A comparative analysis of intraneuronal relationship between Purkinje cells and granule cells zones of the cerebellar cortex molecular layer with different extent of expression of destructive and compensatory-adaptive processes was performed in rats in the dynamics of postischemic period. The ischemia was modelled by the 10 minutes long compression of the heart vascular bundle under the ethereal narcosis, Dependence between type and extent of the synaptic profile and functional state of the synapse was shown. Dynamics of changes of the synapse numerical density was demonstrated so as the regularities of the axo-spinous synapses structural organization changes during their dysfunction, destruction and interneuronal contact repair within and outside the nidi of interneuronal interrelations during 30 days of postischemic period.

摘要

在缺血后时期的动态过程中,对大鼠小脑皮质分子层浦肯野细胞和颗粒细胞区之间神经元内关系进行了比较分析,这些区域具有不同程度的破坏和代偿 - 适应过程表达。通过在乙醚麻醉下对心脏血管束进行10分钟的压迫来模拟缺血,显示了突触轮廓的类型和程度与突触功能状态之间的依赖性。展示了突触数值密度的变化动态,以及在缺血后30天内,在神经元间关系病灶内外,轴 - 棘突触在功能障碍、破坏和神经元间接触修复过程中结构组织变化的规律。

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