Charmes J P, Nicot G, Valette J P, Claude R, Leroux-Robert C
Nouv Presse Med. 1976;5(28):1731-4.
Patients suffering from hepatic cirrhosis develop renal tubular acidosis when subjected to an acid overload. This is characterised by a fall in plasma pH and bicarbonate and by inability of the kidney to lower urine pH and to excrete a sufficient quantity of protons in the form of titratable acidy and ammonia. This disturbance is difficult to explain. It may form part of the picture of the classical functional renal insufficiency of the cirrhotic and may be a particular result of altered renal haemodynamics. Detected by the acidification test, this abnormality may be demonstrated in the absence of any other involvement of renal function. The severity of this renal tubular acidosis would appear to be related to the degree of hepatic disease.
肝硬化患者在遭受酸负荷时会发生肾小管酸中毒。其特征为血浆pH值和碳酸氢盐下降，以及肾脏无法降低尿液pH值并以可滴定酸和氨的形式排泄足够量的质子。这种紊乱难以解释。它可能是肝硬化经典功能性肾功能不全情况的一部分，也可能是肾血流动力学改变的特殊结果。通过酸化试验检测，这种异常可在肾功能无任何其他受累的情况下表现出来。这种肾小管酸中毒的严重程度似乎与肝脏疾病的程度有关。
