Pomfy M, Nicák A
Ustav histológie a embryológie, Univerzity P.J. Safárika v Kosiciach.
Bratisl Lek Listy. 1996 Jun;97(6):365-8.
The state of cerebral ischemia and the following recirculation affect also the blood rheology. The erythrocyte microrheology was studied less than the blood plasma changes. The presented paper is focused on the erythrocyte microrheology changes after global brain ischemia. Both mild and serious global ischemia were induced by the exclusion of cerebral blood circulation for seven min. Thereafter followed the period of recirculation. The changes of erythrocyte microrheology were studied using the method of colloid-osmotic hemolysis. After 180 minutes of recirculation, a significant increase of colloid-osmotic hemolysis was observed. After this until the 240th a significant decrease of colloid-osmotic hemolysis followed. In the group in which mild cerebral ischemia was induced the above mentioned changes were only slightly presented. Important is the fact that the changes in erythrocyte microrheology after serious brain ischemia are in correlation with the changes in cerebral microcirculation. After serious brain ischemia the trombotisation as well as the blood stasis occurred (no-reflow phenomenon).
脑缺血状态及随后的再灌注也会影响血液流变学。对红细胞微观流变学的研究少于对血浆变化的研究。本文聚焦于全脑缺血后红细胞微观流变学的变化。通过阻断脑血液循环7分钟诱导轻度和重度全脑缺血。此后进入再灌注期。使用胶体渗透压溶血法研究红细胞微观流变学的变化。再灌注180分钟后，观察到胶体渗透压溶血显著增加。在此之后直到第240分钟，胶体渗透压溶血显著下降。在诱导轻度脑缺血的组中，上述变化仅轻微出现。重要的是，重度脑缺血后红细胞微观流变学的变化与脑微循环的变化相关。重度脑缺血后发生了血栓形成和血液瘀滞（无复流现象）。
