Tehrani M A, Ledingham I M
Postgrad Med J. 1977 May;53(619):237-42. doi: 10.1136/pgmj.53.619.237.
The author's experience of fourteen patients with necrotizing fasciitis is reviewed. The pathognomonic feature of this condition is an extensive necrosis of subcutaneous tissue caused by a vicious cycle of infection, local ischaemia and reduced host defence mechanisms. The diagnosis can only be confirmed by immediate exploratory incision. The reported mortality of 30-40% reflects the inadaquacy of conservative surgery in the treatment of this serious condition. Mortality can be reduced by early recognition followed by radical excision of the necrotic fascia and overlying skin. The preservation and subsequent use of the excised skin has the advantage of economy in the use of donor areas and reduction in morbidity. Hyperbaric oxygen therapy does not halt the spread of the necrotizing process and is not a substitute for radical surgery.
作者回顾了14例坏死性筋膜炎患者的治疗经验。该病的特征性表现是由感染、局部缺血和宿主防御机制降低的恶性循环导致的皮下组织广泛坏死。诊断只能通过立即进行探查性切开术来证实。报道的30%-40%的死亡率反映了保守手术治疗这种严重疾病的不足。通过早期识别,随后彻底切除坏死的筋膜和覆盖的皮肤,可以降低死亡率。保留并随后使用切除的皮肤具有节省供皮区使用和降低发病率的优点。高压氧治疗不能阻止坏死过程的蔓延,也不能替代根治性手术。