Van Voorhis W C, Barrett L K, Sweeney Y T, Kuo C C, Patton D L
Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, USA.
J Infect Dis. 1996 Sep;174(3):647-50. doi: 10.1093/infdis/174.3.647.
Chlamydia trachomatis infects the upper genital tract of millions of women, causing infertility and pelvic inflammatory disease, yet the inflammatory response to C. trachomatis infection is poorly understood. The cytokine response and the phenotype of infiltrating lymphocytes during C trachomatis infection of fimbria and ampulla autografts in subcutaneous pockets in Macaca nemestrina were characterized. About two-thirds of the infiltrating lymphocytes were CD8 T cells, with the remainder being CD4 T cells and B cells. Interleukin (IL)-2, IL-6, IL-10, interferon-gamma (IFN-gamma), and perforin mRNA were produced by the infiltrating cells, but IL-4 mRNA was absent. The presence of CD8 T cells and perforin mRNA suggest that activated cytolytic T cells are present. The presence of IL-2 and IFN-gamma mRNA and the absence of IL-4 mRNA suggest that Th1-type cytokines predominate during the acute phase of C. trachomatis infection of the upper genital tract.
沙眼衣原体感染数百万女性的上生殖道，导致不孕和盆腔炎，但对沙眼衣原体感染的炎症反应了解甚少。对食蟹猴皮下囊袋中输卵管和壶腹自体移植物进行沙眼衣原体感染时的细胞因子反应及浸润淋巴细胞的表型进行了表征。约三分之二的浸润淋巴细胞为CD8 T细胞，其余为CD4 T细胞和B细胞。浸润细胞产生白细胞介素（IL）-2、IL-6、IL-10、干扰素-γ（IFN-γ）和穿孔素mRNA，但未检测到IL-4 mRNA。CD8 T细胞和穿孔素mRNA的存在表明存在活化的细胞毒性T细胞。IL-2和IFN-γ mRNA的存在以及IL-4 mRNA的缺失表明在上生殖道沙眼衣原体感染急性期Th1型细胞因子占主导。
