MMWR Morb Mortal Wkly Rep. 1996 Aug 9;45(31):665-8.
Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE) in cattle are subacute degenerative diseases of the brain classified as transmissible spongiform encephalopathies. BSE was first identified in 1986 in the United Kingdom (UK), where an epizootic involving > 155,000 cattle appeared to have been greatly amplified by exposure of calves to contaminated rendered cattle carcasses in the form of meat and bone meal nutritional supplements. On March 20, 1996, and expert advisory committee to the government of the UK (1995 estimated population: 58.3 million) announced its conclusion that the agent responsible for BSE might have spread to humans, based on recognition of 10 persons with onset of a reportedly new variant form of CJD during February 1994-October 1995. The 10 persons ranged in age from 16 to 39 years (median age at illness onset: 28 years); of the eight persons who had died, five were aged <30 years. In comparison, in the United States, deaths associated with CJD among persons aged <30 years have been extremely rare (median age at death: 68 years). As a result of the newly recognized variant of CJD described in the UK, CDC updated its previous review of national CJD mortality and began conducting active CJD surveillance in five sites in the United States. These reviews did not detect evidence of the occurrence of the newly described variant form of CJD in the United States.
人类的克雅氏病（CJD）和牛的牛海绵状脑病（BSE）是脑部的亚急性退行性疾病，被归类为传染性海绵状脑病。BSE于1986年在英国首次被发现，在那里，一场涉及超过15.5万头牛的 epizootic似乎因小牛接触以肉骨粉营养补充剂形式存在的受污染牛尸体而大幅加剧。1996年3月20日，英国政府的一个专家咨询委员会（1995年估计人口：5830万）宣布其结论，基于在1994年2月至1995年10月期间识别出10名患有据报道新变异型CJD的患者，认为导致BSE的病原体可能已传播到人类。这10人的年龄在16至39岁之间（发病时的中位年龄：28岁）；在已死亡的8人中，有5人年龄小于30岁。相比之下，在美国，30岁以下人群中与CJD相关的死亡极为罕见（死亡时的中位年龄：68岁）。由于在英国描述的新确认的CJD变异型，美国疾病控制与预防中心（CDC）更新了其先前对全国CJD死亡率的审查，并开始在美国的五个地点进行CJD主动监测。这些审查未发现美国出现新描述的CJD变异型的证据。
