Shi Qi, Zhou Wei, Chen Cao, Gao Chen, Xiao Kang, Wang Jing, Zhang Bao-Yun, Wang Yuan, Zhang Feng, Dong Xiao-Ping
a State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University, Hangzhou), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.
b Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences , Beijing , People's Republic of China.
Prion. 2016 Nov;10(6):484-491. doi: 10.1080/19336896.2016.1229731.
The surveillance of CJD or human prion diseases (PrDs) has been conducted for 10 y in China. To evaluate the quality of China CJD surveillance system, the collections of the clinical and epidemiological information, the sampling, the clinical examinations and laboratory tests and follow-up survey were separately analyzed based on the data from 2010 to 2015. The obtaining rates of clinical-information table, epidemiological-information table, sample inspection sheet and medical record of the referring patients from reporting units to the center of CJD surveillance maintained or reached at very high levels, being close to 100% in the past 3 y. 93.82%, 85.23%, 96.21% and 94.70% of the reported cases had the data of MRI, EEG, CSF 14-3-3 and PRNP sequencing, respectively. Follow-up surveys were conducted in about 50% cases in 2010 and 2011, 93.39% cases in 2012 and 100% cases in the last 3 y. High obtaining rates of the clinical and epidemiological data, high conducting rates of the relevant clinical examinations and laboratory tests, high performing rates of follow-up survey for every referring case reflect a good implemental capacity in China CJD surveillance system, which supplies solid basis for recognition and diagnosis of human prion diseases and guarantees good quality of China CJD surveillance system.
中国开展克雅氏病（CJD）或人类朊病毒病（PrDs）监测已有10年。为评估中国CJD监测系统的质量，基于2010年至2015年的数据，分别对临床和流行病学信息收集、样本采集、临床检查与实验室检测以及随访调查进行了分析。报告单位向CJD监测中心报送转诊患者临床信息表、流行病学信息表、样本检查表和病历的获取率维持或达到了很高水平，过去3年接近100%。分别有93.82%、85.23%、96.21%和94.70%的报告病例有MRI、脑电图（EEG）、脑脊液14-3-3和PRNP测序数据。2010年和2011年约50%的病例进行了随访调查，2012年为93.39%，过去3年为100%。临床和流行病学数据的高获取率、相关临床检查和实验室检测的高开展率、每个转诊病例随访调查的高完成率，反映出中国CJD监测系统具有良好的执行能力，为人类朊病毒病的识别和诊断提供了坚实基础，保证了中国CJD监测系统的良好质量。
