新型克雅氏病与牛海绵状脑病

New variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy.

作者信息

Schonberger L B

机构信息

Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

出版信息

Infect Dis Clin North Am. 1998 Mar;12(1):111-21. doi: 10.1016/s0891-5520(05)70412-8.

DOI:10.1016/s0891-5520(05)70412-8

PMID:9494833

Abstract

New variant Creutzfeldt-Jakob disease (CJD) and bovine spongiform encephalopathy (BSE) are invariably fatal, subacute degenerative diseases of the brain that are classified as transmissible spongiform encephalopathies. BSE was first diagnosed in 1986 as part of an ongoing epizootic in the United Kingdom that was amplified by the feeding of rendered bovine meat-and-bone meal to young calves. As of June 1997, a total of 17 cases of new variant CJD have been reported among residents of the United Kingdom, an increase of seven cases since March 1996, when concern was first expressed about the possible emergence of new variant CJD as a novel epidemic caused by the spread of BSE to humans. Accumulating experimental and epidemiologic data support this concern and have led the CDC to support the Food and Drug Administration's efforts to modify the protein content of ruminant feed in the United States as a prudent measure to protect the health of animals and the public.

摘要

新型克雅氏病（CJD）和牛海绵状脑病（BSE）是 invariably fatal、亚急性脑部退行性疾病，被归类为可传播性海绵状脑病。BSE 于 1986 年首次在英国被诊断出来，是当时正在发生的一场动物流行病的一部分，通过向幼牛喂食加工过的牛肉骨粉而加剧。截至 1997 年 6 月，英国居民中总共报告了 17 例新型 CJD 病例，自 1996 年 3 月首次对新型 CJD 可能作为由 BSE 传播给人类引起的新型流行病出现表示担忧以来，增加了 7 例。越来越多的实验和流行病学数据支持了这一担忧，并导致美国疾病控制与预防中心（CDC）支持美国食品药品监督管理局（FDA）努力修改反刍动物饲料的蛋白质含量，作为保护动物和公众健康的一项审慎措施。