恶性疟原虫急性疟疾后抗中性粒细胞胞浆抗体的检测
Detection of anti-neutrophil cytoplasmic antibodies after acute Plasmodium falciparum malaria.
作者信息
Wenisch C, Wenisch H, Bankl H C, Exner M, Graninger W, Looareesuwan S, Rumpold H
机构信息
Department of Infectious Diseases, Internal Medicine I, University Hospital of Vienna, Austria.
出版信息
Clin Diagn Lab Immunol. 1996 Jan;3(1):132-4. doi: 10.1128/cdli.3.1.132-134.1996.
Abstract
Four of 30 patients with Plasmodium falciparum infection in Bangkok, Thailand, were positive for anti-neutrophil cytoplasmic antibodies by indirect immunofluorescence 1 month after antimalarial therapy. No myeloperoxidase, proteinase 3, lactoferrin, or elastase reactivity was found. Since no evidence of vasculitis was seen in these patients, anti-neutrophil cytoplasmic antibody production in malaria-infected susceptible patients probably represents a secondary response, indicating neutrophil activation.
摘要
在泰国曼谷，30例感染恶性疟原虫的患者中，有4例在抗疟治疗1个月后通过间接免疫荧光法检测抗中性粒细胞胞浆抗体呈阳性。未发现髓过氧化物酶、蛋白酶3、乳铁蛋白或弹性蛋白酶反应性。由于这些患者未出现血管炎证据，疟疾感染易感患者中抗中性粒细胞胞浆抗体的产生可能代表一种继发反应，表明中性粒细胞被激活。
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