可溶性因子与败血症中多形核白细胞失调有关吗？
Are soluble factors relevant for polymorphonuclear leukocyte dysregulation in septicemia?
作者信息
Wenisch C, Graninger W
机构信息
Department of Infectious Diseases, University Hospital of Vienna, Austria.
出版信息
Clin Diagn Lab Immunol. 1995 Mar;2(2):241-5. doi: 10.1128/cdli.2.2.241-245.1995.
Abstract
Polymorphonuclear leukocytes (PMNs) of twelve patients with gram-negative septicemia exhibited a decreased capacity to phagocytize Escherichia coli and generate reactive oxygen products which normalized within 7 days of treatment. Ex vivo exchange of plasma from age-, sex-, and blood-group-identical normal controls resulted in an increase of both phagocytic capacity and reactive oxygen intermediate generation in PMNs of septicemic patients and transiently reduced phagocytosis and reactive oxygen intermediate production in PMNs of normal controls. These results suggest that extrinsic factors are crucial for PMN function.
摘要
12例革兰氏阴性败血症患者的多形核白细胞（PMNs）吞噬大肠杆菌并产生活性氧产物的能力下降，而在治疗7天内恢复正常。用年龄、性别和血型相同的正常对照者的血浆进行体外交换后，败血症患者PMNs的吞噬能力和活性氧中间产物生成均增加，而正常对照者PMNs的吞噬作用和活性氧中间产物生成则短暂减少。这些结果表明，外在因素对PMN功能至关重要。
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