Göransson H, Lehtosalo J, Vuola J, Pätiälä H, Rokkanen P
Department of Orthopaedics and Traumatology, University Central Hospital, Helsinki, Finland.
Scand J Plast Reconstr Surg Hand Surg. 1995 Dec;29(4):281-7. doi: 10.3109/02844319509008961.
Cartilage regeneration was studied in an experiment in rats. A standardised full-thickness articular cartilage defect was created and autogenous 12-day-old callus or cortical bone graft was transplanted into it, or the defect was left empty. The follow up periods were three, six, 12, and 24 weeks, and each subgroup consisted of five animals. A total of 60 animals were operated on. From six weeks onwards hyaline-like cartilaginous tissue had started to develop at the edges of the defect in all three groups. In the middle section of the hole, however, the picture was different; at 24 weeks none of the specimens in the defect group, two of the five in the callus graft group, and all five in the bone graft group had developed full-thickness, hyaline-like cartilaginous regeneration. The hyaline-like cartilaginous tissue in the medical segment was hypocellular when analysed by histomorphometry. On scanning electron microscopy the surface of the reparative tissue looked fibrillated in all specimens from the three groups.
在大鼠实验中研究了软骨再生情况。制造了标准化的全层关节软骨缺损，并将自体12日龄骨痂或皮质骨移植物植入其中，或者让缺损保持空置。随访期为3周、6周、12周和24周，每个亚组由5只动物组成。总共对60只动物进行了手术。从6周起，所有三组缺损边缘均开始出现类似透明软骨的组织。然而，在缺损中部情况不同；24周时，缺损组的所有标本、骨痂移植物组5个标本中的2个以及骨移植物组的所有5个标本均未实现全层、类似透明软骨的再生。通过组织形态计量学分析，内侧部分的类似透明软骨组织细胞较少。扫描电子显微镜观察显示，三组所有标本修复组织的表面均呈纤维状。
