给予华法林的兔子的血浆异常凝血酶原蛋白

Plasma PIVKA proteins in rabbits given warfarin.

作者信息

Zivelin A, Rao L V, Rapaport S I

机构信息

Department of Medicine, University of California, San Diego, USA.

出版信息

Thromb Res. 1996 Jun 1;82(5):429-38. doi: 10.1016/0049-3848(96)00092-8.

DOI:10.1016/0049-3848(96)00092-8

PMID:8771703

Abstract

The presence of partially carboxylated forms of the vitamin K dependent coagulation factors (PIVKA) was evaluated in the plasma of rabbits treated with warfarin. Excess antigen over activity as measured in rabbit specific assays was taken as evidence for PIVKA. Our data confirm a previous report of the absence of plasma PIVKA prothrombin. In contrast, plasma PIVKA factors VII, IX, and X were demonstrable. A striking excess of plasma factor IX antigen over activity was measured and a large fraction of the factor IX antigen persisted in the plasma after its adsorption with barium citrate.

摘要

在接受华法林治疗的家兔血浆中评估了维生素K依赖性凝血因子的部分羧化形式（PIVKA）的存在情况。在家兔特异性检测中测得的抗原活性过量被视为PIVKA的证据。我们的数据证实了之前关于血浆中不存在PIVKA凝血酶原的报道。相比之下，血浆中的PIVKA因子VII、IX和X是可检测到的。检测到血浆因子IX抗原活性显著过量，并且在用柠檬酸钡吸附后，很大一部分因子IX抗原仍存在于血浆中。