水合氯醛/氯胺酮麻醉可维持Wistar大鼠餐后氯化钠平衡的一种形式。
Chloralose/ketamine anaesthesia preserves a form of postprandial sodium chloride balance in Wistar rats.
作者信息
Metz C J, Ise T, Häberle D A
机构信息
Dept. of Physiology, Pettenkoferstr 12, D-80336 Munich, Germany.
出版信息
Pflugers Arch. 1996 Sep;432(5):944-7. doi: 10.1007/s004240050220.
Studies on the mechanisms underlying Na balance in anaesthetized rats are complicated by the fact that the most frequently used barbiturate anaesthetics attenuate or abolish this phenomenon. In the present study we show that a combination of nonbarbiturate anaesthetics: chloralose (140 mg/kg i.v.) and ketamine (30 mg/kg i.m. ), preserve the ability of rats to excrete intragastrically applied NaCl loads dose dependently. Thus rats anaesthetized with this regime excreted 86-102% of in- tragastrically applied NaCl whereas rats anaesthetized with thiobutabarbitone sodium (Inactin) excreted only 20-28%. We conclude that chloralose/ketamine anaesthesia is suitable for studies on Na balance mechanisms.
由于最常用的巴比妥类麻醉剂会减弱或消除这种现象，因此对麻醉大鼠钠平衡潜在机制的研究变得复杂。在本研究中，我们表明非巴比妥类麻醉剂的组合：氯醛糖（140mg/kg静脉注射）和氯胺酮（30mg/kg肌肉注射），能使大鼠以剂量依赖的方式排泄胃内给予的氯化钠负荷。因此，用这种方法麻醉的大鼠排泄了胃内给予的氯化钠的86%-102%，而用硫喷妥钠（Inactin）麻醉的大鼠仅排泄了20%-28%。我们得出结论，氯醛糖/氯胺酮麻醉适用于钠平衡机制的研究。
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