Foley G L, Bassily N, Hess R A
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA.
Toxicol Pathol. 1995 Nov-Dec;23(6):731-4. doi: 10.1177/019262339502300612.
Spermatic granulomas are inflammatory lesions that occur in the efferent ductule and epididymis of humans, goats, rats, and bulls. Three clinically normal dogs from a control group had histologic lesions of the initial segment of the caput epididymis consisting of intratubular spermatic granulomas. The granulomas were located within the efferent ductules, and the inflammatory response consisted primarily of aggregates of spermiophagic macrophages in the ductules. Sperm stasis of the affected ductules was evident by the dilation and accumulation of large numbers of spermatozoa in adjacent cross-sections of efferent ductules. Blind-ending efferent ductules were demonstrated by serially sectioning the initial segment of the epididymis. The intratubular granulomas did not completely occlude the outflow tract because spermatozoa were present in the cauda epididymis. While spermatic granulomas can be induced by trauma, infection, or toxins, spontaneous granulomas due to blind-ending ductules should be considered as a differential. Clinical history, location of the granuloma, and serial sectioning can help determine the most likely etiology in early cases.
精子肉芽肿是发生于人类、山羊、大鼠和公牛的输出小管及附睾的炎性病变。对照组的3只临床正常犬的附睾头起始段存在组织学病变，表现为管内精子肉芽肿。肉芽肿位于输出小管内，炎症反应主要由小管内吞噬精子的巨噬细胞聚集构成。在输出小管的相邻横切面上，大量精子的扩张和聚集表明受累小管存在精子淤滞。通过对附睾起始段进行连续切片，证实存在盲端输出小管。管内肉芽肿并未完全阻塞流出道，因为附睾尾内仍有精子。虽然精子肉芽肿可由创伤、感染或毒素诱发，但应将因盲端小管导致的自发性肉芽肿视为鉴别诊断之一。临床病史、肉芽肿的位置以及连续切片有助于在早期病例中确定最可能的病因。
