Grant L D, Lauwers G Y, Meloni A M, Stone J F, Betz J L, Vogel S, Sandberg A A
University of Florida College of Medicine, Department of Pathology and Laboratory Medicine, Gainesville 32610-0275, USA.
Am J Surg Pathol. 1996 Mar;20(3):339-45. doi: 10.1097/00000478-199603000-00011.
We report on a solid and cystic papillary epithelial neoplasm of the pancreas containing the unbalanced chromosome translocation der(17)t(13;17)(q14;p11), resulting in loss of 13q14-->qter and 17p11-->pter. Although the clinical and pathologic characteristics of this case are largely typical of this uncommon pancreatic neoplasm, the presence of cellular pleomorphism, tumor giant cells, and a DNA tetraploid tumor population suggest that this tumor may have an increased metastatic potential. The unbalanced translocation between chromosomes 13 and 17 and the genes flanking the breakpoints may prove to be markers for solid and cystic papillary epithelial neoplasm of the pancreas and provide insight into its histogenesis.
我们报告了一例胰腺实性假乳头状上皮性肿瘤，其含有不平衡染色体易位der(17)t(13;17)(q14;p11)，导致13q14→qter和17p11→pter缺失。尽管该病例的临床和病理特征在很大程度上是这种罕见胰腺肿瘤的典型表现，但细胞多形性、肿瘤巨细胞以及DNA四倍体肿瘤群体的存在提示该肿瘤可能具有更高的转移潜能。13号和17号染色体之间的不平衡易位以及断点侧翼的基因可能被证明是胰腺实性假乳头状上皮性肿瘤的标志物，并为其组织发生提供见解。
