Alfaro V, Ródenas J, Palaclos L, Mitjavila M T, Carbonell T
Department of Physiology, Faculty of Biology, University of Barcelona, Spain.
Can J Physiol Pharmacol. 1996 Mar;74(3):313-9.
Acidosis has often been reported in inflamed tissues, and changes in strong relevant ions at the site of inflammation may provoke alterations in blood acid-base status. We measured changes in blood acid-base variables during carrageenan-induced inflammation in rats. We found a mixed acid-base disorder in rat blood during acute inflammation (12, 24, and 48 h). A metabolic acid contribution was found during the first 12 h and maintained further, as revealed by a decrease in plasma strong ion concentration difference ([SID]) and an increase in plasma weak acid concentration due to a rise in inorganic phosphate ([ATOT]P(i)). Plasma [SID] and [ATOT]P(i) changes were probably due to exchange of Na+ and P(i) between the inflammatory exudate and rat blood. A secondary respiratory compensation for the metabolic acid changes occurred in the blood of inflamed rats, resulting in significant hypocapnia. Furthermore, a progressive decrease in the total weak acid buffer concentration due to a decrease in plasma albumin ([ATOT]Alb) also counteracted the impact of changes in [SID] and P(i) to increase blood acidity. Therefore, despite the metabolic acid-base disorders induced by inflammatory processes, hydrogen ion (H+) homeostasis was maintained, and blood pH remained essentially unchanged in the inflamed rats.
炎症组织中经常有酸中毒的报道，炎症部位相关强离子的变化可能会引发血液酸碱状态的改变。我们测量了角叉菜胶诱导的大鼠炎症过程中血液酸碱变量的变化。我们发现急性炎症期间（12、24和48小时）大鼠血液中存在混合性酸碱紊乱。在最初的12小时内发现有代谢性酸的影响，并持续存在，这表现为血浆强离子浓度差（[SID]）降低，以及由于无机磷酸盐（[ATOT]P(i)）升高导致血浆弱酸浓度增加。血浆[SID]和[ATOT]P(i)的变化可能是由于炎症渗出液与大鼠血液之间的Na+和P(i)交换所致。炎症大鼠血液中发生了对代谢性酸变化的继发性呼吸代偿，导致显著的低碳酸血症。此外，由于血浆白蛋白（[ATOT]Alb）降低导致总弱酸缓冲浓度逐渐下降，也抵消了[SID]和P(i)变化对增加血液酸度的影响。因此，尽管炎症过程会导致代谢性酸碱紊乱，但氢离子（H+）内环境稳定得以维持，炎症大鼠的血液pH基本保持不变。
