Kläning U, Mortensen P B, Kyvik K O
Institute for Basic Psychiatric Research, Department of Psychiatric Demography, Psychiatric Hospital, Aarhus, Risskov, Denmark.
Br J Psychiatry. 1996 Jun;168(6):688-92. doi: 10.1192/bjp.168.6.688.
We wished to establish whether the occurrence of schizophrenia among twins is the same as among the general population.
Through record linkage between the New Danish Twin Register and the Danish Psychiatric Case Register, the twins who have ever received a diagnosis of schizophrenia were identified. Through indirect standardisation for age, sex and dates of admission, the rate of first admission with diagnosis schizophrenia among twins is compared to the same rate in the general population.
A 28% increase in the rate of first admissions for schizophrenia in twins compared to the general population was found. This is statistically significant and does not seem to be caused by any known methodological problems. Twins also had an increased first-admission rate of any psychiatric disorders.
This increased risk does not seem to be explained by known methodological problems, but does differ from earlier studies.
我们希望确定双胞胎中精神分裂症的发病率是否与普通人群相同。
通过丹麦双胞胎新登记册与丹麦精神病病例登记册之间的记录链接，识别出曾被诊断为精神分裂症的双胞胎。通过对年龄、性别和入院日期进行间接标准化，将双胞胎中首次因精神分裂症诊断入院的比率与普通人群中的相同比率进行比较。
发现双胞胎中精神分裂症首次入院率比普通人群高28%。这具有统计学意义，且似乎并非由任何已知的方法学问题导致。双胞胎中任何精神疾病的首次入院率也有所增加。
这种增加的风险似乎无法用已知的方法学问题来解释，但与早期研究结果不同。
