Endo S, Inada K, Takakuwa T, Kasai T, Yamada Y, Wakabayashi G, Niimi M, Suzuki T, Taniguchi S
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Res Commun Mol Pathol Pharmacol. 1996 May;92(2):253-6.
We assessed the plasma levels of nitrite/nitrate (NOx) and soluble Fas antigen (sFas) in patients with multiple organ failure (MOF). The NOx levels showed high levels in MOF patients with sepsis and without infection. A significant difference was not seen between the MOF patients complicated by sepsis and uncomplicated by infection, although the NOx levels in the former group tended to be higher. There was a significant correlation between NOx levels and sFas levels in MOF patients. Both sFas and NOx levels were high during MOF, and rapidly decreased when MOF was relieved. These findings suggest that sFas and NOx contribute to the development of MOF.
我们评估了多器官功能衰竭（MOF）患者血浆中亚硝酸盐/硝酸盐（NOx）和可溶性Fas抗原（sFas）的水平。NOx水平在伴有脓毒症和不伴有感染的MOF患者中均显示为高水平。尽管伴有脓毒症的MOF患者组中的NOx水平往往更高，但在伴有脓毒症和未伴有感染的MOF患者之间未观察到显著差异。MOF患者的NOx水平与sFas水平之间存在显著相关性。在MOF期间，sFas和NOx水平均较高，而当MOF缓解时迅速下降。这些发现表明，sFas和NOx促成了MOF的发生。
