Gaddum R M, Cook R S, Thomas L H, Taylor G
Institute for Animal Health, Compton, Newbury, Berkshire, UK.
Immunology. 1996 Jul;88(3):421-7. doi: 10.1046/j.1365-2567.1996.d01-667.x.
Bovine respiratory syncytial virus (RSV) is a major cause of respiratory disease in young calves. Recent studies in calves, in which different T-cell subsets were depleted, have shown that CD8+ T cells play a central role in recovery from RSV infection. The present study demonstrates that RSV-specific, major histocompatibility complex-restricted cytotoxic T cells appear in the peripheral blood of gnotobiotic calves 7-10 days after infection with bovine RSV and were also detected in the lungs 10 days after infection. The cytotoxic T lymphocytes (CTL) recognized antigenically distinct strains of bovine RSV. There was no correlation between either the level of CTL activity in the lung or the development of CTL in the peripheral blood and the extent of pneumonic consolidation. The demonstration of CD8+ CTL in the lungs at a time when bovine RSV has been cleared confirms the importance of these cells in recovery from infection.
牛呼吸道合胞病毒（RSV）是幼龄犊牛呼吸道疾病的主要病因。最近在犊牛身上进行的研究，其中不同的T细胞亚群被耗尽，结果表明CD8 + T细胞在从RSV感染中恢复过程中起核心作用。本研究表明，牛RSV感染后7 - 10天，在无菌犊牛的外周血中出现了RSV特异性、主要组织相容性复合体限制性细胞毒性T细胞，感染后10天在肺中也检测到了这种细胞。细胞毒性T淋巴细胞（CTL）识别抗原性不同的牛RSV毒株。肺中CTL活性水平或外周血中CTL的发育与肺实变程度之间均无相关性。在牛RSV已被清除时在肺中证明存在CD8 + CTL，证实了这些细胞在从感染中恢复过程中的重要性。
