Ishida Y, Hayashi M, Higaki A, Matsumoto K, Iikura Y, Ishikawa J, Kida K
Department of Pediatrics, Ehime University School of Medicine, Tokyo, Japan.
J Pediatr. 1996 Mar;128(3):369-72. doi: 10.1016/s0022-3476(96)70284-6.
A patient with hypereosinophilic syndrome simultaneously had generalized myasthenia gravis. Ultrastructural and functional studies demonstrated an increase of the activated hypodense eosinophils. The eosinophilic cationic protein level in plasma and whole blood paralleled the severity of congestive heart failure. A high level of interleukin-5 was detected in both serum and in conditioned medium of T cells by interleukin-2 stimulation before therapy. The findings indicate that both diseases may be associated with a common T-cell abnormality.
一名患有嗜酸性粒细胞增多综合征的患者同时患有全身性重症肌无力。超微结构和功能研究表明活化的低密度嗜酸性粒细胞数量增加。血浆和全血中的嗜酸性粒细胞阳离子蛋白水平与充血性心力衰竭的严重程度平行。治疗前，通过白细胞介素-2刺激在血清和T细胞条件培养基中均检测到高水平的白细胞介素-5。这些发现表明这两种疾病可能与共同的T细胞异常有关。
