Hayashi S, Isobe M, Okubo Y, Suzuki J, Yazaki Y, Sekiguchi M
The First Department of Internal Medicine, Shinshu University, School of Medicine, Asahi, Matsumoto, Japan.
Heart Vessels. 1999;14(2):104-8. doi: 10.1007/BF02481750.
A 62-year-old man with acute eosinophilic endomyocarditis developed congestive heart failure. The biopsy specimens revealed degranulated eosinophils and eosinophil cationic protein (ECP) in the endocardium, and in activated eosinophils and the myocardial interstitium. On electronmicroscopy, a characteristic cardiac myocytolytic change showing disruption at the intercellular junctional site was observed. After steroid treatment, clinical symptoms, systolic dysfunction and laboratory data dramatically improved. In the subsequent biopsy specimens, eosinophilic infiltration and ECP disappeared. Steroid therapy provided a beneficial effect in preventing the progression of cardiac damage. This effect was clearly documented by histochemical studies of the serial endomyocardial biopsy samples.
一名62岁患有急性嗜酸性粒细胞性心内膜炎的男性出现了充血性心力衰竭。活检标本显示心内膜中有脱颗粒的嗜酸性粒细胞和嗜酸性粒细胞阳离子蛋白（ECP），以及活化的嗜酸性粒细胞和心肌间质中也有。电子显微镜检查发现，心肌细胞出现特征性溶解变化，表现为细胞间连接部位的破坏。类固醇治疗后，临床症状、收缩功能障碍和实验室数据显著改善。在随后的活检标本中，嗜酸性粒细胞浸润和ECP消失。类固醇治疗对预防心脏损伤的进展具有有益作用。连续心内膜心肌活检样本的组织化学研究清楚地证明了这一作用。
