Bertrand P, Poirier J, Oda T, Finch C E, Pasinetti G M
Centre for Studies in Aging, McGill University, Montreal, Que, Canada.
Brain Res Mol Brain Res. 1995 Oct;33(1):174-8. doi: 10.1016/0169-328x(95)00097-c.
This study examines the relationship between the levels of apolipoprotein E (apoE) and apolipoprotein J (apoJ, also designated as clusterin) as a function of apoE genotype in the hippocampus and cortex of Alzheimer disease (AD) subjects. These two lipophilic proteins which are involved in the maintenance of lipid homeostasis are both synthesized in the brain by astrocytes. Results indicate a reduction of apoE levels in the hippocampus and frontal cortex that is proportional to the apoE4 allele dose. Conversely, apoJ (clusterin) levels were found to increase proportionately to the number of apoE4 allele dose. These results suggest a compensatory induction of apoJ (clusterin) in the brain of apoE4 AD subjects showing low brain levels of apoE.
本研究探讨了阿尔茨海默病（AD）患者海马体和皮质中载脂蛋白E（apoE）水平与载脂蛋白J（apoJ，也称为聚集素）水平之间的关系，该关系是apoE基因型的函数。这两种参与维持脂质稳态的亲脂性蛋白质均由星形胶质细胞在大脑中合成。结果表明，海马体和额叶皮质中apoE水平的降低与apoE4等位基因剂量成正比。相反，发现apoJ（聚集素）水平与apoE4等位基因剂量的数量成比例增加。这些结果表明，在apoE水平较低的apoE4 AD患者大脑中，apoJ（聚集素）会发生代偿性诱导。
