Kudo M, Asaka M, Kato M, Katagiri M, Kagaya H, Nishikawa K, Koshiyama T, Hokari K, Meguro T, Takeda H
Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
J Clin Gastroenterol. 1995;21 Suppl 1:S174-8.
We conducted a prospective study to evaluate the relationship between Helicobacter pylori infection and chronic gastritis in a Japanese population. H. pylori was found in 67% of patients positive for mononuclear cell (MN cell) infiltration and in 75.8% of patients positive for polymorphonuclear cell (PMN cell) infiltration, whereas H. pylori was found in 14.2% of patients without MN cell infiltration and in 33.2% of patients without PMN cell infiltration. The frequency of MN and PMN cell infiltration in H. pylori-positive patients was significantly higher than that in H. pylori-negative patients. The frequency of H. pylori infection did not differ in those with atrophic gastritis from those without, whereas the frequency of intestinal metaplasia became significantly higher in those with moderate and severe atrophy. There was no significant difference between serum pepsinogen I (PG I) levels in H. pylori-positive and -negative patients. However serum PG II levels were significantly increased in H. pylori-positive patients aged 40-69 years. The serum PG I-II ratio was significantly lower in H. pylori-positive patients aged 40-59 years. These results suggest that H. pylori infection in the gastric mucosa plays an important role in the pathogenesis of chronic and atrophic gastritis and in the development of intestinal metaplasia.
我们进行了一项前瞻性研究，以评估日本人群中幽门螺杆菌感染与慢性胃炎之间的关系。在单核细胞（MN细胞）浸润阳性的患者中，67%检测到幽门螺杆菌；在多形核细胞（PMN细胞）浸润阳性的患者中，75.8%检测到幽门螺杆菌。而在无MN细胞浸润的患者中，14.2%检测到幽门螺杆菌；在无PMN细胞浸润的患者中，33.2%检测到幽门螺杆菌。幽门螺杆菌阳性患者中MN和PMN细胞浸润的频率显著高于幽门螺杆菌阴性患者。萎缩性胃炎患者与非萎缩性胃炎患者的幽门螺杆菌感染率无差异，而在中度和重度萎缩患者中，肠化生的频率显著更高。幽门螺杆菌阳性和阴性患者的血清胃蛋白酶原I（PG I）水平无显著差异。然而，40 - 69岁的幽门螺杆菌阳性患者血清PG II水平显著升高。40 - 59岁的幽门螺杆菌阳性患者血清PG I-II比值显著降低。这些结果表明，胃黏膜中的幽门螺杆菌感染在慢性萎缩性胃炎的发病机制及肠化生的发展中起重要作用。
