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肾刷状缘小泡中胱氨酸与二碱基氨基酸的转运相互作用

Transport interaction of cystine and dibasic amino acids in renal brush border vesicles.

作者信息

Segal S, McNamara P D, Pepe L M

出版信息

Science. 1977 Jul 8;197(4299):169-71. doi: 10.1126/science.877548.

DOI:10.1126/science.877548
PMID:877548
Abstract

The uptake of cystine by vesicles prepared from rat kidney brush borders occurs by two distinct transport systems. The higher affinity system is inhibited by the dibasic amino acids lysine, arginine, and ornithine. The lower affinity system, unaffected by dibasic amino acids, appears to correspond to that observed by studying uptake of cystine by kidney slices.

摘要

从大鼠肾刷状缘制备的囊泡对胱氨酸的摄取通过两种不同的转运系统进行。高亲和力系统受到二碱基氨基酸赖氨酸、精氨酸和鸟氨酸的抑制。低亲和力系统不受二碱基氨基酸的影响,似乎与通过研究肾切片对胱氨酸的摄取所观察到的情况相符。

相似文献

1
Transport interaction of cystine and dibasic amino acids in renal brush border vesicles.肾刷状缘小泡中胱氨酸与二碱基氨基酸的转运相互作用
Science. 1977 Jul 8;197(4299):169-71. doi: 10.1126/science.877548.
2
Transport interactions of cystine and dibasic amino acids in isolated rat renal tubules.胱氨酸和二碱基氨基酸在分离的大鼠肾小管中的转运相互作用。
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3
[Effect of cycloleucine on renal uptake of dibasic amino acids and cystine].
Biomedicine. 1976 Feb 10;25(1):18-22.
4
Renal handling of dibasic amino acids and cystine in cystinuria.胱氨酸尿症中二元氨基酸和胱氨酸的肾脏处理
Clin Sci Mol Med. 1977 Jul;53(1):9-15. doi: 10.1042/cs0530009.
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Cystine and lysine transport in cultured human renal epithelial cells.培养的人肾上皮细胞中的胱氨酸和赖氨酸转运
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Homocystine uptake in isolated rat renal cortical tubules.同型胱氨酸在离体大鼠肾皮质肾小管中的摄取
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7
Lysine transport in human kidney.人肾脏中的赖氨酸转运
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8
Na+-independent L-arginine transport in rabbit renal brush border membrane vesicles.兔肾刷状缘膜囊泡中不依赖钠离子的L-精氨酸转运
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The tubular reabsorption of L-cystine and L-cysteine. A common transport system with L-arginine or not?
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Cystine uptake by rat renal brush-border vesicles.大鼠肾刷状缘小泡对胱氨酸的摄取。
Biochem J. 1981 Feb 15;194(2):443-9. doi: 10.1042/bj1940443.

引用本文的文献

1
Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1.肾近端小管中的新型胱氨酸转运体被鉴定为与胱氨酸尿症相关的质膜蛋白rBAT/SLC3A1缺失的伙伴。
Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):775-80. doi: 10.1073/pnas.1519959113. Epub 2016 Jan 6.
2
Comparative study of the uptake of L-cysteine and L-cystine in the renal proximal tubule.L-半胱氨酸和 L-胱氨酸在肾近端小管中的摄取比较研究。
Amino Acids. 1995 Sep;8(3):247-64. doi: 10.1007/BF00806822.
3
The molecular basis of cystinuria: the role of the rBAT gene.
胱氨酸尿症的分子基础:rBAT 基因的作用。
Amino Acids. 1996 Jun;11(2):225-46. doi: 10.1007/BF00813862.
4
Evidence suggesting that the minimal functional unit of a renal cystine transporter is a heterodimer and its implications in cystinuria.提示肾胱氨酸转运体最小功能单位为异二聚体的证据及其在胱氨酸尿症中的意义。
Amino Acids. 1996 Jun;11(2):209-24. doi: 10.1007/BF00813861.
5
Molecular analysis of cystinuria in Libyan Jews: exclusion of the SLC3A1 gene and mapping of a new locus on 19q.利比亚犹太人胱氨酸尿症的分子分析:排除SLC3A1基因并将一个新基因座定位于19号染色体长臂。
Am J Hum Genet. 1997 Mar;60(3):617-24.
6
Cloning and chromosomal localization of a human kidney cDNA involved in cystine, dibasic, and neutral amino acid transport.参与胱氨酸、二碱基和中性氨基酸转运的人肾cDNA的克隆及染色体定位
J Clin Invest. 1993 May;91(5):1959-63. doi: 10.1172/JCI116415.
7
Cystine uptake by rat renal brush-border vesicles.大鼠肾刷状缘小泡对胱氨酸的摄取。
Biochem J. 1981 Feb 15;194(2):443-9. doi: 10.1042/bj1940443.
8
Reexamination of the interplay between dibasic amino acids and I-cystine/L-cysteine during tubular reabsorption.肾小管重吸收过程中二元氨基酸与L-胱氨酸/L-半胱氨酸之间相互作用的重新审视。
Pflugers Arch. 1982 Nov 11;395(3):196-200. doi: 10.1007/BF00584809.
9
Mutual inhibition of L-cystine/L-cysteine and other neutral amino acids during tubular reabsorption. A microperfusion study in rat kidney.肾小管重吸收过程中L-胱氨酸/L-半胱氨酸与其他中性氨基酸的相互抑制作用。大鼠肾脏的微灌注研究。
Pflugers Arch. 1982 Nov 11;395(3):190-5. doi: 10.1007/BF00584808.
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Membrane transport in the proximal tubule and thick ascending limb of Henle's loop: mechanisms and their alterations.近端小管和髓袢升支粗段的膜转运:机制及其改变
Klin Wochenschr. 1982 Sep 15;60(18):1103-13. doi: 10.1007/BF01715840.