免疫复合物对大鼠小肠杯状细胞黏液释放的刺激作用。
Stimulation by immune complexes of mucus release from goblet cells of the rat small intestine.
作者信息
Walker W A, Wu M, Bloch K J
出版信息
Science. 1977 Jul 22;197(4301):370-2. doi: 10.1126/science.877559.
Immune complexes (bovine serum albumin with rat antibodies to bovine serum albumin) formed in twofold antibody excess were injected into the duodenum of normal rats. In comparison to controls injected with antigen only, there was a marked increase in the percentage of disrupted goblet cells (an index of mucus release) in segments from the intestine of rats exposed for 3 hours to immune complexes in vivo. Similarly, there was a significant increase in 35S-labeled mucus recovered by filtration of intestinal wash, rinse, and mucosal homogenate fluids from rats exposed to immune complexes compared to those from rats exposed to bovine serum albumin or purified rat antiserum to bovine serum albumin alone. These findings suggest that certain immune complexes can stimulate mucus release from intact rat small intestine; enhanced mucus release may have a role in clearing the surface of complexes.
将以两倍抗体过量形成的免疫复合物（牛血清白蛋白与抗牛血清白蛋白的大鼠抗体）注入正常大鼠的十二指肠。与仅注射抗原的对照组相比，在体内暴露于免疫复合物3小时的大鼠肠道段中，杯状细胞破裂百分比（黏液释放指标）显著增加。同样，与暴露于牛血清白蛋白或纯化的抗牛血清白蛋白大鼠抗血清的大鼠相比，暴露于免疫复合物的大鼠经肠道冲洗液、漂洗液和黏膜匀浆过滤回收的35S标记黏液也显著增加。这些发现表明，某些免疫复合物可刺激完整大鼠小肠释放黏液；黏液释放增强可能在清除复合物表面方面发挥作用。
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