Miller H R, Huntley J F, Wallace G R
Immunology. 1981 Oct;44(2):419-29.
AThe phenomenon of rapid expulsion (RE) of Nippostrongylus brasiliensis was examined in Wistar rats. Within 4 hr of intraduodenal challenge with 4 day old N. Brasiliensis greater than 85% of the worms were expelled from rats immunized by infection 18 days previously with 4000-6000 third stage larvae. Rapid expulsion was unaffected by the challenge dose but waned with time after primary infection. Histological observations suggested that the parasites were excluded from their predilection site between the villi in immune rats and that they were separated from the mucosa by a superficial layer of mucus. A newly developed intestinal wash-out technique demonstrated that the 70%-80% of worms in previously uninfected controls were adherent to the mucosa whereas in immune rats 28%-36% of the parasites were adherent and 3%-23% were trapped in mucus. These experiments establish that immune exclusion and mucus trapping are early events in the expulsion process. The possible mechanisms controlling these phenomena are discussed.
对巴西日圆线虫在Wistar大鼠中的快速排出（RE）现象进行了研究。在用4日龄巴西日圆线虫经十二指肠攻击后4小时内，超过85%的蠕虫从18天前经4000 - 6000条第三期幼虫感染而免疫的大鼠体内排出。快速排出不受攻击剂量的影响，但在初次感染后会随时间减弱。组织学观察表明，寄生虫在免疫大鼠的绒毛间偏好部位被排除，并且它们通过一层浅表黏液与黏膜分离。一种新开发的肠道冲洗技术表明，在先前未感染的对照中，70% - 80%的蠕虫附着于黏膜，而在免疫大鼠中，28% - 36%的寄生虫附着，3% - 23%被困于黏液中。这些实验证实免疫排除和黏液捕获是排出过程中的早期事件。并讨论了控制这些现象的可能机制。
