Fujii T, Tsushima R, Okai T, Shibata Y, Taketani Y
Department of Obstetrics and Gynecology, University of Tokyo, Japan.
Int J Gynaecol Obstet. 1996 Mar;52(3):237-42. doi: 10.1016/0020-7292(95)02609-6.
In order to gain insight into the pathogenesis of intrauterine growth restriction (IUGR) of the fetus, we evaluated the cytotoxic activity of lymphocytes towards fetal cells in pregnancies complicated by IUGR.
We performed a cytotoxic assay using the maternal lymphocyte-derived lymphokine activated killer (LAK) cells as the effector cells. Cord vessel endothelial cells were used as the target cells.
LAK cells in pregnancies complicated by IUGR demonstrated higher killer cell activities against IUGR fetus-derived endothelial cells compared with LAK cells from uncomplicated pregnancies against the same endothelial cells. However, when non-IUGR fetus-derived endothelial cells were used as the target cells, LAK cells of pregnant women with IUGR exhibited essentially the same activities as those of normal pregnant women.
The results suggest that lymphocytes in pregnancies complicated by IUGR may have enhanced killer cell activities towards the IUGR fetus in an allo-non-specific way.
为深入了解胎儿宫内生长受限（IUGR）的发病机制，我们评估了合并IUGR的妊娠中淋巴细胞对胎儿细胞的细胞毒性活性。
我们以母体淋巴细胞衍生的淋巴因子激活的杀伤细胞（LAK细胞）作为效应细胞进行细胞毒性测定。脐带血管内皮细胞用作靶细胞。
与未合并IUGR的妊娠中的LAK细胞对相同内皮细胞的杀伤活性相比，合并IUGR的妊娠中的LAK细胞对IUGR胎儿来源的内皮细胞表现出更高的杀伤细胞活性。然而，当使用非IUGR胎儿来源的内皮细胞作为靶细胞时，IUGR孕妇的LAK细胞表现出与正常孕妇基本相同的活性。
结果表明，合并IUGR的妊娠中的淋巴细胞可能以同种异体非特异性方式增强了对IUGR胎儿的杀伤细胞活性。
