Wilting J, Brand-Saberi B, Kurz H, Christ B
Anatomisches Institut, Freiburg, Germany.
Cell Mol Biol Res. 1995;41(4):219-32.
In this article, we survey the mechanisms involved in early embryonic angiogenesis. The first embryonic blood vessels are formed exclusively by endothelial cells. Therefore, the emergence and behavior of this cell type is the center of this article. We discuss both intra- and extraembryonic angiogenesis and the various modes of capillary formation. The high plasticity and migratory potential of endothelial cells and their precursors, the angioblists, are outlined. The promoting and inhibiting influences of the extracellular matrix on the behavior of angioblasts are a matter of concern, as is also the question of embryonic angiogenic factors. Cell-cell interactions that may lead to organ-specific differentiation of endothelial cells are mainly discussed in the context of blood-brain barrier formation and development of fenestrated capillaries. The last section deals with the development of the vascular wall.
在本文中，我们综述了早期胚胎血管生成所涉及的机制。最早的胚胎血管完全由内皮细胞形成。因此，这种细胞类型的出现和行为是本文的核心。我们讨论了胚胎内和胚胎外血管生成以及毛细血管形成的各种模式。概述了内皮细胞及其前体细胞（成血管细胞）的高可塑性和迁移潜能。细胞外基质对成血管细胞行为的促进和抑制作用受到关注，胚胎血管生成因子的问题也是如此。可能导致内皮细胞器官特异性分化的细胞间相互作用主要在血脑屏障形成和有孔毛细血管发育的背景下进行讨论。最后一部分涉及血管壁的发育。
