Kurz H
Institute of Anatomy II, University of Freiburg, Germany.
J Neurooncol. 2000 Oct-Nov;50(1-2):17-35. doi: 10.1023/a:1006485716743.
Angiogenesis is a key prerequisite for growth in all vertebrate embryos and in many tumors. Rapid growth requires efficient transport of oxygen and metabolites. Hence, for a better understanding of tissue growth, biophysical properties of vascular systems, in addition to their molecular mechanisms, need to be investigated. The purpose of this article is twofold: (1) to discuss the biophysics of growing and perfused vascular systems in general, emphasizing non-sprouting angiogenesis and remodeling of vascular plexuses; and (2) to report on cellular details of sprouting angiogenesis in the initially non-perfused embryonic brain and spinal cord. It is concluded that (1) evolutionary optimization of the circulatory system corresponds to highly conserved vascular patterns and angiogenetic mechanisms; (2) deterministic and random processes contribute to both extraembryonic and central nervous system vascularization; (3) endothelial cells interact with a variety of periendothelial cells during angiogenesis and remodeling; and that (4) mathematical models integrating molecular, morphological and biophysical expertise improve our understanding of normal and pathological angiogenesis and account for allometric relations.
血管生成是所有脊椎动物胚胎和许多肿瘤生长的关键先决条件。快速生长需要高效运输氧气和代谢产物。因此，为了更好地理解组织生长，除了分子机制外，还需要研究血管系统的生物物理特性。本文的目的有两个：（1）总体讨论生长和灌注血管系统的生物物理学，重点是非芽生血管生成和血管丛重塑；（2）报告最初未灌注的胚胎脑和脊髓中芽生血管生成的细胞细节。得出的结论是：（1）循环系统的进化优化对应于高度保守的血管模式和血管生成机制；（2）确定性和随机过程对胚胎外和中枢神经系统血管化都有贡献；（3）血管生成和重塑过程中，内皮细胞与多种周内皮细胞相互作用；（4）整合分子、形态学和生物物理专业知识的数学模型有助于我们更好地理解正常和病理性血管生成，并解释异速生长关系。
