Fernhall B, Pitetti K H, Rimmer J H, McCubbin J A, Rintala P, Millar A L, Kittredge J, Burkett L N
Exercise Science, The George Washington University, Washington, DC, USA.
Med Sci Sports Exerc. 1996 Mar;28(3):366-71. doi: 10.1097/00005768-199603000-00012.
This study evaluated the cardiorespiratory capacity of persons with MR with and without Down syndrome. Analyses of individual data records of maximal exercise tests with metabolic analyses were conducted on tests of 111 subjects (31 men and 16 women with DS; 35 men and 29 women without DS) from six participating centers. All centers used a walking treadmill protocol previously shown to produce valid and reliable maximal tests with this population. Peak oxygen uptake and peak minute ventilation were higher in men than in women (P < 0.006), and in subjects without DS (P < 0.006). Peak heart rate was also higher in subjects without DS (P < 0.006). Peak respiratory exchange ratio (RER) was higher in subjects without DS (P < 0.006). Using peak RER as a covariate did not change the results. An analysis of peak minute ventilation, heart rate and VO2 of subjects with a peak RER above 1.1 revealed the same results. These data show that individuals with mental retardation have low levels of peak VO2, consistent with low levels of cardiovascular fitness. Individuals with Down syndrome have even lower levels of peak VO2 than their peers without Down syndrome, a finding that is possibly mitigated by the lower peak heart rates of the individuals with Down syndrome.
本研究评估了患有和未患有唐氏综合征的智力障碍者的心肺功能。对来自六个参与中心的111名受试者（31名患有唐氏综合征的男性和16名女性；35名未患有唐氏综合征的男性和29名女性）的最大运动测试的个体数据记录进行了代谢分析。所有中心均采用了先前已证明对该人群能产生有效且可靠的最大测试结果的步行跑步机方案。男性的峰值摄氧量和峰值每分通气量高于女性（P < 0.006），且未患有唐氏综合征的受试者中也是如此（P < 0.006）。未患有唐氏综合征的受试者的峰值心率也更高（P < 0.006）。未患有唐氏综合征的受试者的峰值呼吸交换率（RER）更高（P < 0.006）。将峰值RER作为协变量进行分析并未改变结果。对峰值RER高于1.1的受试者的峰值每分通气量、心率和VO2进行分析，得出了相同的结果。这些数据表明，智力障碍者的峰值VO2水平较低，这与心血管健康水平较低相一致。患有唐氏综合征的个体的峰值VO2水平甚至低于未患有唐氏综合征的同龄人，这一发现可能因患有唐氏综合征的个体较低的峰值心率而有所缓解。
