Wahr J A, Yun J H, Yang V C, Lee L M, Fu B, Meyerhoff M E
Department of Anesthesiology, University of Michigan, Ann Arbor, USA.
J Cardiothorac Vasc Anesth. 1996 Jun;10(4):447-50. doi: 10.1016/s1053-0770(05)80002-3.
To determine the ability of a new electrochemical sensor to determine heparin levels in whole blood and to correlate the heparin levels as determined by this heparin-responsive sensor (HRS) with heparin levels as determined by the Hepcon assay system (Medtronic Hemotec, Parker, CO).
Methods comparison study.
A large academic medical center.
The heparin levels of 162 samples from 24 patients undergoing cardiopulmonary bypass were determined by the HRS system and by the Hepcon system. In 21 samples, heparin levels as measured by anti-Xa activity were determined as well.
HRS-determined values correlated highly with Hepcon-determined values (r = 0.942) and with anti-Xa determined values (r = 0.905). Bias +/- precision comparing the HRS and Hepcon methods was 0.211 +/- 0.478 U/mL.
HRS determined that whole blood heparin levels correlate well with Hepcon-determined levels. These limited results indicate that further development and testing of this new technology are warranted.
确定一种新型电化学传感器测定全血中肝素水平的能力，并将这种肝素反应性传感器（HRS）测定的肝素水平与Hepcon检测系统（美敦力血液技术公司，科罗拉多州派克市）测定的肝素水平进行关联。
方法比较研究。
一家大型学术医疗中心。
采用HRS系统和Hepcon系统测定24例接受体外循环患者的162份样本的肝素水平。对其中21份样本，还测定了通过抗Xa活性测得的肝素水平。
HRS测定值与Hepcon测定值高度相关（r = 0.942），与抗Xa测定值也高度相关（r = 0.905）。比较HRS和Hepcon方法的偏差±精密度为0.211±0.478 U/mL。
HRS测定的全血肝素水平与Hepcon测定的水平相关性良好。这些有限的结果表明，这项新技术值得进一步开发和测试。
