Gräsbeck A, Rorsman B, Hagnell O, Isberg P E
Department of Psychiatry, Lund University, Sweden.
Neuropsychobiology. 1996;33(3):118-26. doi: 10.1159/000119261.
The mortality of anxiety syndromes between 1972 and 1992 was investigated in a prospective study of a normal population, the 1947 Lundby cohort. 121 persons with anxiety according to the Lundby definition (Anx), and 74 persons with panic disorder with/without agoraphobia (PD-Ag) according to the DSM-III-R, all of them developing their first episode between 1947 and 1972, were analyzed with regard to general mortality and special cause of death. Sex- and age-specific mortality rates for these groups were calculated and compared with the corresponding rates of the cohort's 1,877 remaining subjects without first episodes of Anx/PD-Ag. In contrast to the females, the annual rates of general mortality in males with Anx/PD-Ag were 1.9/2.2 times higher in the age group 65-84 years, compared with the rates of the non-Anx/PD-Ag groups. They also had an increase in death due to circulatory disorders, most pronounced in males with PD-Ag before the age of 65. There were no suicides in any of the Anx/PD-Ag groups during the observation period.
在一项针对正常人群（1947年隆德比队列）的前瞻性研究中，对1972年至1992年间焦虑综合征的死亡率进行了调查。根据隆德比定义有焦虑症的121人（Anx），以及根据《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）患有伴有/不伴有广场恐惧症的惊恐障碍（PD-Ag）的74人，他们均在1947年至1972年间首次发病，对其总体死亡率和具体死因进行了分析。计算了这些组别的性别和年龄特异性死亡率，并与该队列中1877名没有Anx/PD-Ag首次发作的其余受试者的相应死亡率进行了比较。与女性不同，65 - 84岁年龄组中患有Anx/PD-Ag的男性总体死亡率年率比非Anx/PD-Ag组高1.9/2.2倍。他们因循环系统疾病导致的死亡也有所增加，在65岁之前患有PD-Ag的男性中最为明显。在观察期内，任何Anx/PD-Ag组中均未出现自杀情况。
