Gräsbeck A, Hansson F, Rorsman B, Sigfrid I, Hagnell O
Department of Clinical Neuroscience, Lund University, Sweden.
Acta Psychiatr Scand. 1998 Jul;98(1):14-22. doi: 10.1111/j.1600-0447.1998.tb10036.x.
The aim of the present study was to analyse first-incidence anxiety in the Lundby Study with regard to course and predictors of outcome between 1947 and 1972. The Lundby concept of anxiety corresponds broadly to that of anxiety disorders in DSM-III-R. The Lundby Study is a prospective, psychiatric study of a geographically defined total population. The present study includes 124 subjects (46 men and 78 women) who between 1947 and 1972 developed anxiety as their first mental illness in life. The median total duration of illness was 1.6 years in men and 1.4 years in women. In both sexes episodes of mild impairment dominated. In total, 54% of the men and 71% of the women were mentally healthy at the follow-up in 1972. A minority of the probands (27%) received psychiatric treatment. They significantly more often suffered from panic disorder with agoraphobia during their first episode, and from comorbidity of other mental illnesses, than did untreated subjects. They also had a significantly longer total duration of illness, a variable with a negative predictive influence on the probability of being mentally healthy in 1972. Men with anxiety showed a 55% increase in alcoholism compared to standard values. They also displayed an increased risk of relapsing into mental illness compared to female cases, a result which, in the light of earlier findings of increased mortality rates, suggests that further investigations of men with anxiety syndromes in the general population are warranted.
本研究的目的是分析伦德比研究中1947年至1972年间首次发病的焦虑症的病程及预后预测因素。伦德比的焦虑概念与《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）中的焦虑症概念大致相符。伦德比研究是一项针对特定地理区域总人口的前瞻性精神病学研究。本研究纳入了124名受试者（46名男性和78名女性），他们在1947年至1972年间首次患上焦虑症，这是他们一生中的首次精神疾病。男性的疾病总持续时间中位数为1.6年，女性为1.4年。在两性中，轻度损害发作占主导。总体而言，在1972年的随访中，54%的男性和71%的女性心理健康。少数先证者（27%）接受了精神科治疗。与未接受治疗的受试者相比，他们在首次发作时更常患有伴有广场恐惧症的惊恐障碍，以及其他精神疾病的共病。他们的疾病总持续时间也显著更长，这一变量对1972年心理健康的可能性具有负面预测影响。患有焦虑症的男性与标准值相比，酗酒率增加了55%。与女性病例相比，他们复发精神疾病的风险也增加了，鉴于早期发现的死亡率上升结果，这表明有必要对普通人群中患有焦虑综合征的男性进行进一步研究。
