Ancoli-Israel S, Kripke D F, Klauber M R, Fell R, Stepnowsky C, Estline E, Khazeni N, Chinn A
Department of Psychiatry, University of California San Diego, USA.
Sleep. 1996 May;19(4):277-82. doi: 10.1093/sleep/19.4.277.
A population-based probability sample of elderly individuals (n = 426), who were originally studied between 1981 and 1986 (mean age at initial study was 72.5 years), were followed for mortality. Those with > or = 30 respiratory disturbances per hour of sleep had significantly shorter survival (p = 0.0034), but the respiratory disturbance index (RDI) was not an independent predictor of death. When Cox proportional hazards analysis was done, only age (the strongest predictor), cardiovascular disease and pulmonary disease were independent predictors of death. It may be that factors that are secondary to or associated with sleep-disordered breathing (SDB), such as cardiovascular or pulmonary disease, predispose these elderly to death.
对426名老年人进行了基于人群的概率抽样，这些老年人最初在1981年至1986年期间接受研究（初始研究时的平均年龄为72.5岁），随后对其进行了死亡率随访。每小时睡眠中呼吸紊乱≥30次的人存活时间显著缩短（p = 0.0034），但呼吸紊乱指数（RDI）并非死亡的独立预测因素。进行Cox比例风险分析时，只有年龄（最强的预测因素）、心血管疾病和肺部疾病是死亡的独立预测因素。可能是睡眠呼吸紊乱（SDB）继发或与之相关的因素，如心血管或肺部疾病，使这些老年人易发生死亡。
