Bliwise D L, Bliwise N G, Partinen M, Pursley A M, Dement W C
Sleep Disorders Center, Stanford University Medical School, CA 94305.
Am J Public Health. 1988 May;78(5):544-7. doi: 10.2105/ajph.78.5.544.
In the aged, sleep may be a vulnerable period for death from cardiovascular causes. Because of its high prevalence in the elderly, sleep apnea has been suggested to be one mechanism contributing to such sleep-related mortality. In this study, a cohort of 198 non-institutionalized elderly individuals (mean age at entry = 66) were followed for periods up to 12 years after initial polysomnography. The mortality ratio for sleep apnea (defined as a Respiratory Disturbance Index of over 10 events per sleep hour) was estimated to be 2.7 (95% CI = .95, 7.47). Multiple regression with the Cox proportional hazards model suggested that cardiovascular death was most clearly associated with age in this cohort. These results raise the possibility that "natural" death during sleep in the elderly may be associated with specific pathophysiological events during sleep.
在老年人中，睡眠可能是心血管疾病致死的一个易发生时段。由于睡眠呼吸暂停在老年人中高发，它被认为是导致此类与睡眠相关死亡率的一种机制。在本研究中，一组198名非机构养老的老年人（入组时平均年龄 = 66岁）在首次多导睡眠监测后随访了长达12年。睡眠呼吸暂停（定义为每睡眠小时呼吸紊乱指数超过10次事件）的死亡率估计为2.7（95%置信区间 = 0.95，7.47）。使用Cox比例风险模型进行的多元回归表明，在该队列中，心血管死亡与年龄最密切相关。这些结果增加了一种可能性，即老年人睡眠期间的“自然”死亡可能与睡眠期间特定的病理生理事件有关。
