Linazasoro G
Unidad de Parkinson y Trastornos del Movimiento, Clínica Quirón, País Vasco, Spain.
Clin Neuropharmacol. 1996 Apr;19(2):171-6. doi: 10.1097/00002826-199619020-00006.
Despite recent advances in the understanding of gait disorders in the elderly, little is known about the precise neurochemical mechanism that underlies such conditions. To determine the neurochemical basis of freezing, an apomorphine test was carried out in 21 patients with freezing associated with Parkinson's disease (11 patients) or with a higher level gait disorder (10 patients). The test was positive in parkinsonian patients with freezing exclusively during "off" periods (n = 9). In these cases, there were a parallel improvement in motor function. The remaining 12 patients (two with Parkinson's disease and unpredictable freezing, eight with subcortical dysequilibrium, and two with isolated gait-ignition failure) failed to improve throughout the test period. We conclude that freezing may be the consequence of different neurochemical disturbances, although a common neural substrate cannot be excluded.
尽管最近在理解老年人步态障碍方面取得了进展，但对于导致此类情况的精确神经化学机制仍知之甚少。为了确定冻结现象的神经化学基础，对21例与帕金森病相关的冻结患者（11例）或伴有高级步态障碍的患者（10例）进行了阿扑吗啡试验。该试验在仅在“关”期出现冻结的帕金森病患者中呈阳性（n = 9）。在这些病例中，运动功能同时得到改善。其余12例患者（2例帕金森病伴不可预测的冻结、8例皮质下失衡和2例孤立性步态启动失败）在整个试验期间均未改善。我们得出结论，尽管不能排除存在共同的神经基质，但冻结可能是不同神经化学紊乱的结果。
