复发性韦格纳肉芽肿：环孢素A治疗成功

Relapsing Wegener's granulomatosis: successful treatment with cyclosporin-A.

作者信息

Georganas C, Ioakimidis D, Iatrou C, Vidalaki B, Iliadou K, Athanassiou P, Kontomerkos T

机构信息

Department of Rheumatology, District General Hospital of Athens, Greece.

出版信息

Clin Rheumatol. 1996 Mar;15(2):189-92. doi: 10.1007/BF02230339.

DOI:10.1007/BF02230339

PMID:8777855

Abstract

We describe the case of a 32-year-old splenectomised man with severe Wegener's granulomatosis which was refractory to conventional treatment with oral cyclophosphamide and prednisolone. Remission was temporarily induced only with plasma exchange or i.v. immunoglobulin. Because of frequent relapses of the disease and cyclophosphamide side effects, he was started on treatment with cyclosporin-A and a long lasting remission was achieved.

摘要

我们描述了一名32岁的脾切除男性患者的病例，该患者患有严重的韦格纳肉芽肿，对口服环磷酰胺和泼尼松龙的传统治疗无效。仅通过血浆置换或静脉注射免疫球蛋白暂时诱导了缓解。由于疾病频繁复发以及环磷酰胺的副作用，他开始接受环孢素A治疗，并实现了长期缓解。