Aikiä M, Kälviäinen R, Riekkinen P J
Department of Neurology, Kuopio University Hospital, Finland.
Epilepsy Res. 1995 Oct;22(2):157-64. doi: 10.1016/0920-1211(95)00042-9.
Verbal learning and memory of 56 adults with newly diagnosed partial epilepsy and no other known brain pathology were compared with memory performance of a normal control group. Memory was evaluated with a list learning test and with recall of logical prose under both immediate and delayed recall conditions. The patients and the controls did not differ in immediate and delayed recall of logical prose. Also learning and immediate recall of the word list was comparable in both groups. After delay the patients recalled fewer words than the control group (P < 0.001), and the percent retention of words was lower in the patients (P < 0.001). The patients with newly diagnosed epilepsy more frequently exhibited mild verbal memory dysfunction as shown in delayed recall of word list. Moderate memory impairment is seen in a group of patients who have deficits in immediate and delayed memory. Follow-up is needed to find out whether patients with memory deficits at the time of diagnosis are those who develop intractable chronic epilepsy.
将56名新诊断为部分性癫痫且无其他已知脑部病变的成年人的言语学习和记忆与正常对照组的记忆表现进行了比较。通过列表学习测试以及在即时和延迟回忆条件下对逻辑性散文的回忆来评估记忆。患者和对照组在逻辑性散文的即时和延迟回忆方面没有差异。两组在单词列表的学习和即时回忆方面也具有可比性。延迟后,患者回忆的单词比对照组少(P < 0.001),患者的单词保留率也较低(P < 0.001)。新诊断为癫痫的患者在单词列表的延迟回忆中更频繁地表现出轻度言语记忆功能障碍。在一组即时和延迟记忆都有缺陷的患者中可见中度记忆损害。需要进行随访以确定诊断时存在记忆缺陷的患者是否会发展为顽固性慢性癫痫。