Delville Y, Mansour K M, Ferris C F
Department of Psychiatry, University of Massachusetts Medical Center, Worcester 01655, USA.
Physiol Behav. 1996 Apr-May;59(4-5):813-6. doi: 10.1016/0031-9384(95)02166-3.
In golden hamsters, vasopressin (AVP) microinjected within the ventrolateral hypothalamus (VLH) facilitates offensive aggression. As serotonin is known to inhibit offensive aggression, we decided to test whether AVP-facilitated behavior is also inhibited by serotonin treatment. Testosterone-treated male golden hamsters received IP injections of fluoxetine, a serotonin reuptake inhibitor, or vehicle 1 h prior to AVP microinjections within the VLH. The animals were tested for offensive aggression in a resident-intruder model after the microinjections, and the results were compared between groups. Pretreatment with fluoxetine inhibited AVP-facilitated offensive aggression. Only one out of nine fluoxetine-treated animals attacked and bit the intruders, compared to six out of seven vehicle-treated animals. Furthermore, we also confirmed by in vitro autoradiography that the VLH contains vasopressin V(1) and serotonin 5-HT1B receptors. Therefore, it is possible that serotonin may inhibit AVP-facilitated offensive aggression by acting directly at the level of the VLH as well as at other sites.
在金黄地鼠中，向腹外侧下丘脑（VLH）微量注射加压素（AVP）会促进攻击性攻击行为。由于已知血清素会抑制攻击性攻击行为，我们决定测试血清素治疗是否也会抑制AVP促进的行为。经睾酮处理的雄性金黄地鼠在向VLH微量注射AVP前1小时腹腔注射血清素再摄取抑制剂氟西汀或赋形剂。微量注射后，在居住者 - 入侵者模型中测试动物的攻击性攻击行为，并比较各组结果。氟西汀预处理抑制了AVP促进的攻击性攻击行为。九只接受氟西汀治疗的动物中只有一只攻击并咬伤了入侵者，而七只接受赋形剂治疗的动物中有六只出现这种情况。此外，我们还通过体外放射自显影证实，VLH含有加压素V(1)和血清素5-HT1B受体。因此，血清素有可能通过直接作用于VLH水平以及其他部位来抑制AVP促进的攻击性攻击行为。
