Anderson D E, Fedorova O V, French A W
Laboratory of Behavioral Sciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224, USA.
Physiol Behav. 1996 Apr-May;59(4-5):857-61. doi: 10.1016/0031-9384(95)02165-5.
Previous studies found that regular confinement of dogs in an experimental environment preceding onset of an avoidance task was associated with increases in blood pressure and decreases in heart rate and respiration rate that were not prevented by adrenergic antagonists. The present study investigated a) whether divergent changes in blood pressure and heart rate also occur in micropigs preceding onset of an avoidance task, and b) the nature of changes in blood gases, plasma pH, plasma bicarbonate, hematocrit, and plasma electrolytes observed under these conditions. Blood pressure increased and heart rate decreased during 2-h preavoidance periods, whereas both blood pressure and heart rate were elevated during 20-min avoidance periods. During preavoidance periods, pO2, plasma pH, and plasma potassium pCO2 were decreased below home kennel levels during early preavoidance, whereas pCO2 and plasma bicarbonate were persistently increased and hematocrit was persistently decreased for the duration of the preavoidance periods. Each of these changes was reversed during the avoidance sessions. These findings suggest that behaviorally induced hypercapnia might participate in blood pressure regulation via increased renal sodium/hydrogen exchange and renal sodium retention.
先前的研究发现，在回避任务开始前，将狗定期关在实验环境中，会导致血压升高、心率和呼吸频率降低，且这些变化不受肾上腺素能拮抗剂的影响。本研究调查了：a）在回避任务开始前，小型猪是否也会出现血压和心率的不同变化；b）在这些条件下观察到的血气、血浆pH值、血浆碳酸氢盐、血细胞比容和血浆电解质的变化性质。在回避前的2小时内，血压升高，心率降低，而在20分钟的回避期内，血压和心率均升高。在回避前阶段，早期回避时pO2、血浆pH值和血浆钾pCO2低于犬舍水平，而在整个回避前阶段，pCO2和血浆碳酸氢盐持续升高，血细胞比容持续降低。在回避期，这些变化均得到逆转。这些发现表明，行为诱导的高碳酸血症可能通过增加肾钠/氢交换和肾钠潴留参与血压调节。
